Recent years have been characterized by a gradual increase in the interaction between Law and Neuroscience, thanks to the advancement of Cognitive Neuroscience and to the advent of neuroimaging tools aimed at exploring the morphological and dynamic aspects of the brain. The fundamental question is to what extent the contribution of Neuroscience can change the behavior of lawyers. In this review, we summarize the current neuroscientific evidences and the expectations of the Law in respect of Neuroscience.